Several upper level microfluidic large scale integration chips have been developed and published. A selection of these are available upon request if you would like to use them for your assays and applications. The following lists pre-designed microfluidic chips available to you and reference articles which describe their structure and functionality in detail:
Protein Crystallography - Screening Chip
Hansen CL, Skordalakes E, Berger JM, Quake SR, "A Robust and Scalable Microfluidic Metering Method that Allows Protein Crystal Growth by Free Interface Diffusion", Proc. Nat'l Acad. Sci. 99: 16531-6 (2002). (pdf)
Protein Crystallography - Formulator Chip
Hansen CL, Sommer MO, Quake SR. "Systematic investigation of protein phase behavior with a microfluidic formulator." Proc. Natl. Acad. Sci . 2004 Oct 5;101(40):14431-6. (pdf)
Protein Crystallography - Harvesting Chip
Hansen CL, Classen S, Berger JM, Quake SR. "A microfluidic device for kinetic optimization of protein crystallization and in situ structure determination" J. Am. Chem. Soc. 2006 Mar 15;128(10):3142-3. (pdf)
Microchemostat Chip
Balagadde FK, You L, Hansen CL, Arnold FH, and Quake SR. "Long-term monitoring of bacteria undergoing programmed population control in a microchemostat." Science . 2005 Jul 1;309(5731):137-40. (pdf)
Single Cell Analysis Chip
Marcus JS, Anderson WF, Quake SR. "Microfluidic Single-Cell mRNA Isolation and Analysis" Anal. Chem. 2006 Mar 31;10.1021/ac0518506
In addition to these, other chip designs from Quake group are becoming available, please send an email to stanford.foundry@gmail.com for more information.
